Research vision
The Andersson lab focuses on modeling gene regulation to gain insights into molecular mechanisms by which enhancer or promoter dysregulation contributes to disease risk.
We take an interdisciplinary approach and combine machine learning, statistical learning, genetics, and molecular biology to:
- determine which noncoding sequences act as enhancers, which genes they regulate and in which cell types
- learn how the human genome encodes regulatory activity
- characterize the mechanisms that control gene expression variation
Learn more about our research or browse our publications.
Team
The lab is based in the Section for Computational and RNA Biology, Department of Biology, University of Copenhagen.
We are also affiliated with the Enhpathy Marie Sklodowska-Curie actions (MSCA)-ITN-ETN,
the Novo Nordisk Foundation Center for Genomics Mechanisms of Disease, the Gene Regulation Observatory (GRO), and the FANTOM consortium.
Learn more about the team.
Want to join the team? Excellent postdoc and PhD student candidates interested in gene regulation are encouraged to contact Robin Andersson.
Representative work
- Andersson R, et al. An atlas of active enhancers across human cell types and tissues. Nature. 2014
- Rennie S, et al. Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities. Nucleic Acids Research. 2018
- Einarsson H, et al. Promoter sequence and architecture determine expression variability and confer robustness to genetic variants. Elife. 2022
- van Duin L, et al. Transcription factor expression is the main determinant of variability in gene co-activity. Molecular Systems Biology. 2023
- Wenger, et al. Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. Nature Genetics. 2023
See our full list of publications.
Past and present funders
Andersson Lab 